Acting locally: innate mucosal immunity in resistance to HIV-1 infection in Kenyan commercial sex workers
نویسندگان
چکیده
منابع مشابه
HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan sex workers.
OBJECTIVES Most HIV-1 transmission is sexual; therefore, immune responses in the genital mucosa may be important in mediating protection against HIV infection. This study examined HIV-1-specific mucosal IgA in a cohort of HIV-1-resistant Kenyan female sex workers. METHODS HIV-1-specific immune responses were compared in HIV-1-resistant and HIV-1-infected sex workers, and in lower risk uninfec...
متن کاملHIV-1 RNA Dysregulates the Natural TLR Response to Subclinical Endotoxemia in Kenyan Female Sex-Workers
BACKGROUND Subclinical endotoxemia has been reported in HIV-1 infected persons and may drive systemic immune activation and pathogenesis. Proinflammatory responsiveness to endotoxin (LPS) is mediated by Toll-like receptor 4 (TLR4). We therefore examined the association between plasma LPS levels, HIV RNA, and TLR4 expression and cytokine responses in the blood of HIV infected and uninfected part...
متن کاملA common CD4 gene variant is associated with an increased risk of HIV-1 infection in Kenyan female commercial sex workers.
BACKGROUND It has been predicted that CD4 C868T, a novel CD4 single-nucleotide polymorphism (SNP) that has been found to be highly prevalent among Africans, changes the tertiary structure of CD4, which may alter susceptibility to human immunodeficiency virus (HIV) infection. METHODS Participants were from a Kenyan cohort and included 87 uninfected and 277 HIV-1-infected individuals. DNA seque...
متن کاملHIV infection and sexually transmitted diseases in female commercial sex workers in China.
A cross-sectional survey was conducted among female commercial sex workers (FSWs) in Zhengzhou, China, to estimate rates of HIV infection and sexually transmitted diseases (STDs) and to document their sexual behavior patterns from October 2000 to January 2001. FSWs were recruited by the snowball sampling technique and were interviewed at their working environments anonymously. This strategy res...
متن کاملInnate Immunity to Mucosal Candida Infections
Mucosal epithelial tissues are exposed to high numbers of microbes, including commensal fungi, and are able to distinguish between those that are avirulent and those that cause disease. Epithelial cells have evolved multiple mechanisms to defend against colonization and invasion by Candida species. The interplay between mucosal epithelial tissues and immune cells is key for control and clearanc...
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ژورنال
عنوان ژورنال: Mucosal Immunology
سال: 2013
ISSN: 1933-0219,1935-3456
DOI: 10.1038/mi.2013.44